GM2A Polyclonal Antibody for Human(Homo sapiens) | EIAab.comGM2A Polyclonal Antibody for Human(Homo sapiens)

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GM2A (Gene name),

Ganglioside GM2 activator (Protein name ), SAP3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GM2A;

Protein name:

Ganglioside GM2 activator;

Alternative:

GM2-AP;Cerebroside sulfate activator protein;Shingolipid activator protein 3(SAP-3);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

Subcellular Location:

Lysosome

Protein Attributes:

Sequence length:

193

Sequence:

50:

100:

150:

193:

EFVVPDLELP | SWLTTGNYRI | ESVLSSSGKR | LGCIKIAASL | KGI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

272750

String:

P17900

KEGG:

hsa:2760

UniGene:

Hs.483873

Pfam:

PF02221

SMR:

P17900

STRING:

9606.ENSP00000349687

Uniprot:

P17900

FOR

ELISA Kit for Human Ganglioside GM2 activator

Cat.:

E2403h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Ganglioside GM2 activator

Cat.:

E2403m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Ganglioside GM2 activator

Cat.:

U2403h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Ganglioside GM2 activator

Cat.:

U2403m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Ganglioside GM2 activator

Cat.:

P2403Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ganglioside GM2 activator

Cat.:

P2403Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Ganglioside GM2 activator

Protein for Human Ganglioside GM2 activator

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and expression of a full-length cDNA encoding the human G-M2 activator protein."
Xie B. , McInnes B. , Neote K. , Lamhonwah A.-M. , Mahuran D.
Biochem. Biophys. Res. Commun.177:1217-1223(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-59 AND VAL-69
2.

"Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein."
Klima H. , Tanaka A. , Schnabel D. , Nakano T. , Schroeder M. , Suzuki K. , Sandhoff K.
FEBS Lett.289:260-264(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-19; VAL-59 AND VAL-69
3.

"Evidence for two cDNAs encoding human GM2-activator protein."
Nagarajan S. , Chen H.C. , Li S.C. , Li Y.T. , Lockyer J.
Biochem. J.282:807-813(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
4.

"Identification of a processed pseudogene related to the functional gene encoding the GM2 activator protein: localization of the pseudogene to human chromosome 3 and the functional gene to human chromosome 5."
Xie B. , Kennedy J.L. , McInnes B. , Auger D. , Mahuran D.J.
Genomics14:796-798(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-19; VAL-59 AND VAL-69
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS THR-19 AND VAL-69
tissue: Substantia nigra.
6.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Structure of the GM2A gene: identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2."
Chen B. , Rigat B. , Curry C. , Mahuran D.J.
Am. J. Hum. Genet.65:77-87(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-19; VAL-59 AND VAL-69
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-59 AND VAL-69
tissue: Uterus.
10.

"Isolation of a cDNA encoding the human GM2 activator protein."
Schroeder M. , Klima H. , Nakano T. , Kwon H. , Quintern L.E. , Gaertner S. , Suzuki K. , Sandhoff K.
FEBS Lett.251:197-200(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-193;VARIANTS THR-19; VAL-59 AND VAL-69
11.

"The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein."
Furst W. , Schubert J. , Machleidt W. , Meyer H.E. , Sandhoff K.
Eur. J. Biochem.192:709-714(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-193
tissue: Kidney.
12.

"Crystal structure of human GM2-activator protein with a novel beta-cup topology."
Wright C.S. , Li S.-C. , Rastinejad F.
J. Mol. Biol.304:411-422(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
13.

"A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB."
Schroeder M. , Schnabel D. , Suzuki K. , Sandhoff K.
FEBS Lett.290:1-3(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2GAB ARG-138
14.

"Molecular genetics of GM2-gangliosidosis AB variant: a novel mutation and expression in BHK cells."
Schroder M. , Schnabel D. , Hurwitz R. , Young E. , Suzuki K. , Sandhoff K.
Hum. Genet.92:437-440(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2GAB PRO-169
15.

"Molecular analysis of a GM2-activator deficiency in two patients with GM2-gangliosidosis AB variant."
Schepers U. , Glombitza G. , Lemm T. , Hoffmann A. , Chabas A. , Ozand P. , Sandhoff K.
Am. J. Hum. Genet.59:1048-1056(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2GAB LYS-88 DEL

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